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Updated: Aug 8, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
Instrumentation of high temperature and pressure reaction system with continuous flow and its hyphenation to a liquid
Takao Tsuda1, Shinya Kitagawa, Takayuki Umeyama
1Department of Materials Science and Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa, Japan. tsuda@pico-device.co.jp
Abstract:
A continuous flow-type hydrothermal reaction system, in which both temperature and pressure were rapidly and dynamically controlled, was constructed. It is called a real time high temperature and pressure reaction system (RT-HighTP). The RT-HighTP was hyphenated with liquid chromatograph (RT-HighTP-LC) to achieve prompt analysis of the reaction products. The RT-HighTP system produced stable pressure under the supercritical and subcritical phases (%RSD < 3%). The RT-HighTP-LC was able to change the hydrothermal condition rapidly. The hydrothermal products under four conditions were analyzed within 70 min. Further, the hydrothermal products of lignin was easily taken out using the sample collecting loop and analyzed by an external instrument of GC/MS.
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