Related Experiment Video

Updated: Aug 8, 2026

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Characteristics of in-hospital onset ischemic stroke

Kazumi Kimura1, Kazuo Minematsu, Takenori Yamaguchi

  • 1Cerebrovascular Division, Department of Medicine, National Cardiovascular Center, Osaka, Japan. kimurak@med.kawasaki-m.ac.jp

European Neurology
|May 31, 2006
PubMed

Insights

In-hospital stroke onset, while not uncommon, is associated with more severe neurological deficits and worse outcomes. Implementing strategies to reduce in-hospital strokes is crucial for improving patient prognosis.

Area of Science:

  • Neurology
  • Public Health
  • Clinical Medicine

Background:

  • In-hospital onset stroke represents a significant clinical concern.
  • Understanding its characteristics is vital for patient care improvement.

Purpose of the Study:

  • To elucidate the clinical features of strokes occurring during hospitalization.
  • To compare in-hospital stroke onset with out-of-hospital onset events.

Main Methods:

  • Analysis of 15,815 acute brain infarction patients from the J-MUSIC registry.
  • Comparison of clinical characteristics, severity (NIHSS), and mortality between in-hospital and out-of-hospital onset stroke groups.

Main Results:

  • In-hospital stroke onset occurred in 4.4% of patients.
  • In-hospital strokes were linked to higher rates of atrial fibrillation (AF), greater initial neurological deficits (NIHSS), and increased mortality.
  • Female gender, older age, AF, prior stroke history, and in-hospital onset independently predicted severe stroke.

Conclusions:

  • In-hospital stroke onset is a notable occurrence.
  • Patients experiencing in-hospital strokes exhibit more severe deficits and poorer outcomes.
  • Strategies to mitigate in-hospital stroke incidence are recommended.
Abstract

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...