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A Pre-Clinical Model of Synovitis Using Ex vivo Human Synovial Tissue with Preserved Function and Architecture
Published on: March 20, 2026
[Synovial biopsy under US guidance: technical considerations and results]
F Marin1, J Lasbleiz, J D Albert
1Département de Radiologie et d'Imagerie Médicale, Hôpital Sud, BP 90347, 35203 Rennes Cedex 2.
Journal De Radiologie
|May 31, 2006
Summary
Ultrasound (US) guided synovial membrane biopsy is a safe and effective diagnostic tool for monoarthritis. This minimally invasive procedure shows a high success rate with no complications, outperforming fluoroscopic guidance.
Area of Science:
- Rheumatology
- Radiology
- Pathology
Background:
- Monoarthritis of unknown etiology requires accurate diagnosis.
- Synovial membrane biopsy is crucial for identifying underlying causes.
- Minimally invasive diagnostic techniques are preferred.
Purpose of the Study:
- To describe and assess the efficacy and safety of ultrasound (US) guided synovial membrane biopsy.
- To compare the success rate of US guided biopsy with fluoroscopic guided biopsy.
Main Methods:
- Eighty-three patients with monoarthritis underwent US guided synovial membrane biopsy between 2002 and 2005.
- Procedure involved real-time ultrasonographic guidance for optimal needle placement.
- Complications were monitored via continuous ultrasonographic scanning.
Main Results:
- Synovial tissue was successfully obtained in 94% of cases across various peripheral joints.
- Specific success rates included shoulder (100%), knee (97%), and ankle (100%).
- No complications were reported during or after the biopsy procedures.
Conclusions:
- Ultrasound guided synovial membrane biopsy is a safe and highly effective diagnostic method.
- The technique offers significant advantages over traditional fluoroscopic guided biopsies.
- US guidance enables precise targeting and complication monitoring for improved patient outcomes.