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[Clinical pathways in endocrinology and diabetology]

B Gallwitz1, H Lehnert, H Dittmann

  • 1Abteilung IV der Medizinischen Klinik, Universitätsklinikum, Otfried-Müller-Strasse 10, 72076, Tübingen. baptist.gallwitz@med.uni-tuebingen.de

Der Internist
|May 31, 2006
PubMed

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Type II Diabetes II: Pathophysiology

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Type I Diabetes II: Pathophysiology01:26

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Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
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