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Acute ischemic stroke and hypothyroidism.

Kerri S Remmel¹, Anna Wanahita, Kari Moore

¹Stroke Center, Department of Neurology, University of Louisville, Louisville, Kentucky 40202, USA. Kremmel@pol.net

The Journal of the Kentucky Medical Association

|June 1, 2006

Summary

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Hypothyroidism is common in patients experiencing acute ischemic stroke (AIS) or transient ischemic attack (TIA). This condition, linked to higher homocysteine levels, may be a modifiable stroke risk factor.

Area of Science:

Neurology
Endocrinology
Public Health

Background:

Stroke incidence and mortality are notably high in Kentucky.
Modifiable risk factors are key to stroke prevention.
Hypothyroidism is associated with altered lipid metabolism and hyperhomocysteinemia, suggesting a potential link to stroke.

Purpose of the Study:

To investigate the association between hypothyroidism and acute ischemic stroke (AIS) or transient ischemic attack (TIA).

Main Methods:

Retrospective review of consecutive patients diagnosed with AIS or TIA at the University of Louisville Stroke Center.

Main Results:

12% of patients with AIS or TIA were diagnosed with hypothyroidism.
Hyperhomocysteinemia prevalence was significantly higher in hypothyroid patients (45.4%) compared to euthyroid patients (27.8%).

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Conclusions:

Hypothyroidism is a prevalent condition among AIS and TIA patients.
Elevated homocysteine levels in hypothyroid patients suggest it may be a modifiable stroke risk factor.
Further prospective studies are required to confirm this association.