Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokine single nucleotide polymorphisms in Iran.

Mortaza Bagheri1, Davood Omrani, Isa Abdi-Rad

  • 1Faculty of Medicine, Genetic Department, Uromieh Medical Sciences University, Uromieh, Iran. m_bagheri@umsu.ac.ir

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|June 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exome sequencing reveals neurodevelopmental genes in simplex consanguineous Iranian families with syndromic autism.

BMC medical genomics·2024
Same author

Analysis of Cytogenetic Abnormalities in Iranian Patients with Syndromic Autism Spectrum Disorder: A Case Series.

Iranian journal of child neurology·2022
Same author

Analysis of Interleukin-17 mRNA Level in the Urinary Cells of Kidney Transplant Recipients with Stable Function.

Maedica·2018
Same author

Vitamin D Receptor Gene Haplotype and Late-Onset Obesity in Iranian Azeri Turkish Women.

Maedica·2017
Same author

Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping.

American journal of human genetics·2017
Same author

An Association Study between INSR/NsiI (rs2059806) and INSR/PmlI (rs1799817) SNPs in Women with Polycystic Ovary Syndrome from West Azerbaijan Province, Iran.

Journal of reproduction & infertility·2015

This study analyzed cytokine gene single nucleotide polymorphisms (SNPs) in healthy Iranians. Findings reveal distinct allele and genotype frequencies compared to other Asian and African American populations.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Population Genetics

Background:

  • Cytokine gene expression and secretion are influenced by genetic variations.
  • Single nucleotide polymorphisms (SNPs) in cytokine genes can affect immune responses.
  • Understanding these variations is crucial for comparative population genetics.

Purpose of the Study:

  • To determine the allelic and genotypic frequencies of various cytokine SNPs in a healthy Iranian population.
  • To compare the cytokine genetic profiles of Iranians with other global populations.
  • To identify potential genetic markers influencing immune system variations.

Main Methods:

  • Polymerase Chain Reaction-Sequence Specific Primers (PCR-SSP) assay was employed for genotyping.
  • Analysis included multiple cytokine genes such as IL-1alpha, IL-1beta, IL-12, IFN-gamma, TGF-beta, TNF-alpha, IL-2, IL-4, IL-6, IL-10, IL-1R, IL-1RA, and IL-4RA.

Related Experiment Videos

  • Allelic and genotypic frequencies were calculated for 40 healthy Iranian subjects.

    • Main Results:

    • The study determined the prevalence of specific cytokine SNPs in the Iranian cohort.
    • Iranian cytokine profiles showed similarities to European populations (Italian, English, German, Greek).
    • Significant differences in allele and genotype frequencies were observed when comparing Iranians to certain Asian and African American populations.

    Conclusions:

    • The genetic landscape of cytokine polymorphisms in Iranians presents a unique profile.
    • These findings highlight population-specific variations in immune-related genes.
    • Further research can explore the functional implications of these observed genetic differences in immune function.