Related Experiment Video
Updated: Aug 8, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Effects of bioactive glass on bone augmentation within a titanium cap in rabbit parietal bone
Tetsuya Nishida1, Yutaka Yamada, Masakazu Murai
1Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan. nishida@dent.nihon-u.ac.jp
Background:
The condition of alveolar bone influences the success and subsequent esthetics of implant treatment. This study investigated the early effects of bioactive glass (BG) on bone augmentation within a hemispherical titanium cap in rabbit parietal bone.
Methods:
Twelve adult male Japanese white rabbits were used. One titanium cap (test site) was packed with BG in a collagen gel, and the other (control site) was packed with the collagen gel alone. After 1 and 3 months, animals were euthanized, and the experimental area was examined using fluorescence and light microscopy.
Results:
Newly generated bone was observed at 1 and 3 months of healing. Although bone was also generated without BG, newly mineralized bone was generated sooner with BG present for guided bone augmentation than without BG. At 1 and 3 months, the BG was not bioabsorbed completely, and some particles remained.
Conclusion:
New bone is generated at an early stage of bone formation using BG for bone augmentation.
