Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The ICln interactome.

J Fürst1, G Bottà, S Saino

  • 1Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria.

Acta Physiologica (Oxford, England)
|June 1, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Speciation within the <i>Anopheles gambiae</i> complex: high-throughput whole genome sequencing reveals evidence of a putative new cryptic taxon in 'far-west' Africa.

Research square·2024
Same author

Conjugate treatment with high concentration normobaric oxygen and hyaluronic acid for vaginal atrophy: a prospective study.

European review for medical and pharmacological sciences·2023
Same author

Dual role of miR-1 in the development and function of sinoatrial cells.

Journal of molecular and cellular cardiology·2021
Same author

Vapor phase processing: a novel approach for fabricating functional hybrid materials.

Nanotechnology·2020
Same author

Evaluating human basal metabolism: the erroneous and misleading use of so-called "prediction equations".

International journal of food sciences and nutrition·2019
Same author

First Report of Soybean Rust Caused by Phakopsora pachyrhizi on Phaseolus spp. in Argentina.

Plant disease·2019

Understanding protein interactions is key to explaining cellular functions. This study details the ICln interactome, revealing its role as a central

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Mammalian cells exhibit complex functional phenotypes (>250 K) not explained by the limited number of independently expressed proteins (<25 K).
  • Protein-protein interactions (interactome) are crucial for understanding cellular complexity and function.
  • The protein ICln has diverse reported functions, including ion permeation, cytoskeletal organization, and RNA processing.

Purpose of the Study:

  • To elucidate the interactome of the ICln protein.
  • To understand the role of ICln as a potential 'connector hub' in cellular processes.

Main Methods:

  • Literature review and data compilation on known ICln interactions.
  • Analysis of ICln's role in different functional modules based on existing studies.

Related Experiment Videos

Main Results:

  • The ICln interactome is presented, consolidating current knowledge.
  • ICln acts as a 'connector hub' and 'date hub', linking diverse cellular functions.
  • Evidence suggests ICln integrates ion permeation, cytoskeletal organization, and RNA processing pathways.

Conclusions:

  • The ICln interactome is essential for understanding its multifaceted cellular roles.
  • ICln's function as a hub protein is critical for explaining the complexity of mammalian cell phenotypes.
  • Further research into the ICln interactome will advance our understanding of cellular regulation.