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Published on: November 8, 2011
Hairy cell transformation of a B-cell chronic lymphocytic leukemia: a morphological, cytochemical, phenotypic and
E Duchayne1, G Delsol, E Kuhlein
1Laboratoire de Cytologie et Cytogénétique, CRTS, Purpan, Toulouse, France.
Leukemia
|February 1, 1991
Abstract:
The normal counterparts of the B cells found in hairy cell leukemia (HCL) are not known. We report here a detailed morphological, cytochemical, immunological and molecular analysis of a patient with B-cell chronic lymphocytic leukemia (B-CLL) who later in the course of his disease developed hairy cell leukemia. We speculate that hairy cell transformation of B-CLL might be related to an in vivo protein kinase C mediated cellular activation of B-CLL cells.
