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Vobasinyl-iboga bisindole alkaloids, potent acetylcholinesterase inhibitors from Tabernaemontana divaricata root

Kornkanok Ingkaninan1, Kanokwan Changwijit, Khanit Suwanborirux

  • 1Department of Pharmaceutical Chemistry and Pharmacognosy, Naresuan University, Phitsanulok 65000, Thailand. k_ingkaninan@yahoo.com

The Journal of Pharmacy and Pharmacology
|June 1, 2006
PubMed

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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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