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m-Carborane bisphenol structure as a pharmacophore for selective estrogen receptor modulators

Takumi Ogawa1, Kiminori Ohta, Tomohiro Yoshimi

  • 1Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

Bioorganic & Medicinal Chemistry Letters
|June 1, 2006
PubMed
Summary

Researchers developed novel m-carborane derivatives to target estrogen receptors. One derivative showed significantly higher estrogen receptor agonistic activity, suggesting potential for new selective estrogen receptor modulators (SERMs) in cancer therapy.

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