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Updated: Aug 8, 2026

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
Published on: March 13, 2019
Evaluation of synthetic linear motor-molecule actuation energetics
Branden Brough1, Brian H Northrop, Jacob J Schmidt
1Department of Mechanical and Aerospace Engineering, Institute for Cell Mimetic Space Exploration, and California Nanosystems Institute, University of California, Los Angeles, CA 90095, USA.
Abstract:
By applying atomic force microscope (AFM)-based force spectroscopy together with computational modeling in the form of molecular force-field simulations, we have determined quantitatively the actuation energetics of a synthetic motor-molecule. This multidisciplinary approach was performed on specifically designed, bistable, redox-controllable [2]rotaxanes to probe the steric and electrostatic interactions that dictate their mechanical switching at the single-molecule level. The fusion of experimental force spectroscopy and theoretical computational modeling has revealed that the repulsive electrostatic interaction, which is responsible for the molecular actuation, is as high as 65 kcal.mol(-1), a result that is supported by ab initio calculations.
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