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Related Experiment Videos

Imprinting disorders after assisted reproductive technologies.

Øjvind Lidegaard1, Anja Pinborg, Anders Nyboe Andersen

  • 1Gynaecologic Clinic Juliane, Marie Centre, Copenhagen, Denmark. lidegaard@dadlnet.dk

Current Opinion in Obstetrics & Gynecology
|June 1, 2006
PubMed
Summary
This summary is machine-generated.

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The risk of imprinting diseases in children conceived via assisted reproductive technologies (ART) appears limited. While case reports suggest a link, large-scale studies show no significant increase, warranting further research.

Area of Science:

  • Reproductive Medicine
  • Epigenetics
  • Pediatric Health

Background:

  • Imprinting disorders arise from disruptions in epigenetic programming during gametogenesis, fertilization, or early embryonic development.
  • Existing literature includes case reports suggesting a potential association between imprinting diseases and assisted reproductive technologies (ART).

Purpose of the Study:

  • To evaluate the current evidence regarding an elevated risk of imprinting diseases in children conceived through ART.

Main Methods:

  • Review of published case and case-reference reports.
  • Analysis of two large national systematic follow-up studies on children conceived via in-vitro fertilization (IVF).

Main Results:

  • Ten case reports suggested a higher proportion of imprinting diseases in ART-conceived children, but lacked consistency and detailed genetic analysis.

Related Experiment Videos

  • Large-scale studies of Danish (6052 children) and Swedish (16,280 children) IVF-conceived children found zero and two cases of imprinting diseases, respectively.
  • These observed rates align with the expected incidence in the general population.

    • Conclusions:

    • The current evidence for an increased risk of imprinting diseases following ART is limited.
    • Published case reports highlight the need for systematic, multinational, long-term follow-up studies of ART-conceived children.