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Related Experiment Videos

Secreted modular calcium-binding protein-1 localization during mouse embryogenesis.

Nikolaus Gersdorff1, Matthias Müller, Antje Schall

  • 1Department of Prosthodontics, Georg-August-Universität Göttingen, 37075 Göttingen, Germany.

Histochemistry and Cell Biology
|June 1, 2006
PubMed
Summary

Secreted modular calcium-binding protein-1 (SMOC-1) is found in basement membranes during mouse embryonic development. Its widespread expression suggests diverse roles in embryogenesis.

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Area of Science:

  • Biochemistry
  • Developmental Biology
  • Extracellular Matrix Research

Background:

  • BM-40 is an extracellular matrix protein with calcium-binding and follistatin-like domains.
  • Secreted modular calcium-binding protein-1 (SMOC-1) is a novel BM-40 family member.
  • SMOC-1 possesses thyroglobulin-like domains, a follistatin-like domain, and a unique domain.

Purpose of the Study:

  • To investigate the localization and expression of SMOC-1 during mouse embryogenesis.
  • To determine the potential roles of SMOC-1 in embryonic development.

Main Methods:

  • Immunofluorescence and immunogold electron microscopy for localization in adult tissues.
  • Light microscopic immunohistochemistry for localization in early mouse embryos.
  • Analysis of SMOC-1 mRNA synthesis in embryonic cells.

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Main Results:

  • SMOC-1 is localized in basement membranes of various adult murine tissues, including skin, blood vessels, brain, kidney, muscle, and oocyte zona pellucida.
  • In early mouse embryos (day 7), SMOC-1 is present in the endodermal basement membrane zone.
  • SMOC-1 mRNA is synthesized by cells from all three germ layers.
  • From embryonic day 12 through fetal stages (14, 16, 18), SMOC-1 is found in basement membranes of numerous organs.

Conclusions:

  • SMOC-1 exhibits ubiquitous expression in adult tissues and a specific distribution in embryonic basement membranes.
  • The broad and organ-specific expression pattern suggests multifunctional roles for SMOC-1 in mouse embryogenesis.