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Hepatic tuberculosis presenting as cholestatic jaundice. A case report
1Rajasthan Hospital and Sterling Hospital, Ahmedabad. mkghoda@yahoo.com
Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|June 2, 2006
Summary
Hepatic tuberculosis can cause cholestatic jaundice, even without biliary obstruction. Prompt anti-tuberculous treatment leads to recovery in these unusual liver manifestations.
Area of Science:
- Hepatology
- Infectious Diseases
- Gastroenterology
Background:
- Tuberculosis (TB) is a common infectious disease globally.
- Hepatic involvement in tuberculosis is often considered a histopathological finding rather than a distinct clinical entity.
- Cholestatic jaundice is a less common presentation of hepatic tuberculosis.
Observation:
- Three patients presented with cholestatic jaundice, anorexia, fever, weight loss, and hepatomegaly.
- No evidence of biliary obstruction was found in any of the patients.
- Two patients had concurrent extrahepatic tuberculosis, while one did not.
Findings:
- Liver biopsy confirmed hepatic tuberculosis as the cause of cholestatic jaundice.
- The study highlights unusual clinical presentations of hepatic tuberculosis.
- All patients demonstrated a positive response to anti-tuberculous therapy.
Implications:
- These cases suggest hepatic tuberculosis should be considered in the differential diagnosis of cholestatic jaundice, especially in endemic areas.
- Early diagnosis and treatment of hepatic tuberculosis can lead to complete recovery.
- Further research is warranted to understand the pathogenesis and clinical spectrum of hepatic tuberculosis.