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Related Experiment Videos

Spinophilin: from partners to functions.

D Sarrouilhe1, A di Tommaso, T Métayé

  • 1Laboratoire de Physiologie Humaine, Faculté de Médecine et Pharmacie, 34, rue du Jardin-des-Plantes, BP 199, 86005 Poitiers cedex, France. Denis.Sarrouilhe@univ-poitiers.fr

Biochimie
|June 2, 2006
PubMed
Summary

Spinophilin is a versatile protein scaffold involved in cytoskeletal and membrane functions. It plays key roles in the nervous system, regulating spine morphology, synaptic plasticity, and neuronal migration, and influences cell growth.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Neuroscience

Background:

  • Spinophilin, also known as neurabin 2, interacts with protein phosphatase 1 (PP1) and F-actin.
  • It possesses multiple modular domains (e.g., F-actin, SH3, PDZ, coiled-coil, LIZ) mediating diverse protein-protein interactions.

Purpose of the Study:

  • To review the known protein partners of spinophilin.
  • To elucidate the functional roles of spinophilin based on its interactions and structural domains.

Main Methods:

  • Gene analysis and biochemical approaches were used to define spinophilin's structure and domains.
  • Identification of over 30 spinophilin partner proteins through various experimental methods.

Main Results:

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  • Spinophilin acts as a multifunctional scaffold, regulating cytoskeletal and membrane functions.
  • It is crucial in the nervous system for spine morphology, synaptic plasticity, and neuronal migration.
  • Spinophilin influences seven-transmembrane receptor signaling and cell growth, notably through interaction with ARF.

    • Conclusions:

    • Spinophilin is a key regulator of cellular processes, particularly in neuronal development and signaling.
    • Its diverse interactions highlight its role as a central hub in cellular communication and organization.