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Updated: Aug 8, 2026
14:51
Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
Published on: November 13, 2021
Proteomics in clinical trials and practice: present uses and future promise
Nilofer S Azad1, Nabila Rasool, Christina M Annunziata
1Laboratory of Pathology, Molecular Signaling Section, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.
Molecular & Cellular Proteomics : MCP
|June 2, 2006
Summary
Clinical proteomics offers new ways to find cancer biomarkers for early diagnosis and personalized therapies. Advanced technologies are improving protein analysis for more effective treatments.
Area of Science:
- Clinical proteomics
- Biomarker discovery
- Molecular medicine
Background:
- Clinical proteomics involves studying proteins to understand disease.
- Expression proteomics analyzes protein differences between healthy and diseased states.
- Functional proteomics investigates protein interactions and pathways in disease.
Purpose of the Study:
- To highlight the potential of clinical proteomics in oncology.
- To discuss the applications of expression and functional proteomics.
- To emphasize advancements in proteomics technologies for clinical trials.
Main Methods:
- Evaluating differential protein expression and post-translational modifications.
- Deciphering protein-protein interactions and biochemical pathways.
- Utilizing advanced spectrometry and protein array technologies.
Main Results:
- Biomarkers identified can aid in early diagnosis, prognosis, and therapy response prediction.
- Proteomics advancements are being applied in clinical trials.
- Improved analyses lead to more effective, tailored therapies.
Conclusions:
- Clinical proteomics has significant applications in oncology.
- Advancements in proteomics pave the way for personalized molecular medicine.
- Future proteomics technology could revolutionize disease diagnosis and treatment.
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