Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dermal dendrocytes and photochemotherapy.

G E Piérard1, A Nikkels, J Arrese Estrada

  • 1Department of Dermatopathology, University of Liège, Belgium.

Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recommendations for skin cancer consultation and surgery during COVID-19 pandemic.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Practical recommendations for systemic treatment in psoriasis according to age, pregnancy, metabolic syndrome, mental health, psoriasis subtype and treatment history (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 1).

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Should we provide anti-human papillomavirus vaccination for patients with genital hidradenitis suppurativa?

The British journal of dermatology·2018
Same author

Vitamin D supplementation in cutaneous malignant melanoma outcome (ViDMe): a randomized controlled trial.

BMC cancer·2017
Same author

[Vitamin D anti-cancer activities: observations, doubts and certainties].

Revue medicale de Liege·2016

Psoralens and ultraviolet light alter dermal dendrocytes, immune cells in the skin. These changes, including increased numbers and altered distribution, may affect skin immunity and connective tissue, especially with early photosclerosis.

Area of Science:

  • Dermatology
  • Immunology
  • Photobiology

Background:

  • Dermal dendrocytes are key immune cells in the skin.
  • Psoralen and ultraviolet A (PUVA) therapy is used for various skin conditions.
  • The precise effects of PUVA on dermal dendrocytes are not fully understood.

Purpose of the Study:

  • To investigate the impact of psoralens and ultraviolet light (PUVA) on dermal dendrocytes.
  • To characterize the morphological and numerical changes in dermal dendrocytes following PUVA treatment.

Main Methods:

  • Immunohistochemistry was used to identify Factor-XIIIa-positive dermal dendrocytes.
  • Computerized image analysis quantified changes in cell number, size, and distribution.
  • Histological assessment correlated changes with the presence of photosclerosis.

Related Experiment Videos

Main Results:

  • Factor-XIIIa-positive dermal dendrocytes showed significant alterations after PUVA treatment.
  • Increased numbers, uneven size, and altered tissue distribution of dermal dendrocytes were observed.
  • Cytoplasmic fragmentation of dermal dendrocytes was noted, particularly in cases with early photosclerosis.

Conclusions:

  • PUVA therapy induces notable changes in dermal dendrocytes.
  • These alterations likely reflect associated vascular changes and may contribute to PUVA's immunomodulatory effects.
  • Dermal dendrocyte changes may play a role in the disruption of skin connective tissue structure induced by PUVA.