Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrical remodeling in atrial fibrillation.

Dobromir Dobrev1

  • 1Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany. dobrev@rcs.urz.tu-dresden.de

Herz
|June 2, 2006
PubMed
Summary

Electrical remodeling, changes promoting atrial fibrillation (AF), involves ion channels and calcium regulators. Understanding these molecular changes in AF offers targets for antiarrhythmic therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PulseSelect vs FARAPULSE pulsed field ablation: Comparative analysis of myocardial, neural-injury and hemolysis biomarkers and short-term outcomes.

International journal of cardiology. Heart & vasculature·2026
Same author

Computational modeling identifies protective mechanisms of estrogen and testosterone against atrial fibrosis.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Bile Acids Rewiring Cardiometabolic Systems.

The Canadian journal of cardiology·2026
Same author

Immunology of Cardiometabolic Health and Disease: From Novelty to Necessity.

The Canadian journal of cardiology·2026
Same author

Antiplatelet Therapy and All-Cause Mortality After Transcatheter Aortic Valve Replacement: The TRITAVI Registry.

JACC. Advances·2026
Same author

Potentially futile outcome after uncomplicated TAVI: Insights from the TRITAVI registry.

American heart journal·2026

Area of Science:

  • Cardiology
  • Electrophysiology
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) is linked to electrical remodeling, altering heart rhythm.
  • Ion channels, gap junctions, and calcium homeostasis are key molecular players in AF.
  • Understanding these molecular determinants is crucial for AF management.

Purpose of the Study:

  • To review the cellular and molecular basis of electrical remodeling in AF.
  • To identify potential molecular mechanisms underlying AF.
  • To highlight putative molecular targets for antiarrhythmic drug development.

Main Methods:

  • Literature review of cellular and molecular studies on atrial electrical remodeling in AF.
  • Analysis of research on ion channels, gap junctions, and intracellular calcium regulation in AF.
  • Synthesis of findings to identify therapeutic targets.

Main Results:

  • Electrical remodeling in AF involves significant alterations in ion channel function and expression.
  • Dysregulation of intracellular calcium (Ca2+) handling is a critical component of AF pathophysiology.
  • Gap junction remodeling further contributes to the electrical instability promoting AF.

Conclusions:

  • Altered electrical properties of the atria in AF are driven by specific molecular changes.
  • Targeting identified molecular pathways, including ion channels and calcium regulators, may offer novel antiarrhythmic strategies.
  • Further research into these molecular mechanisms is essential for developing effective AF therapies.

Related Experiment Videos