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Published on: June 14, 2015
Comparison of exercise effects on the hemodynamics of the Bio 14.6 cardiomyopathic hamster
S S Awad1, J D Welty, A R al-Muhailan
1Department of Physiology Faculty of Medicine, Kuwait University, Safat.
Insights
Exercise training improved cardiac function in cardiomyopathic hamsters and altered cardiovascular parameters in normal hamsters. Both 4 and 16 weeks of exercise positively impacted heart function, with longer durations showing more pronounced effects.
Area of Science:
- Cardiology
- Exercise Physiology
- Comparative Physiology
Background:
- Heart disease in hamsters can lead to impaired cardiac function.
- Exercise is a known modulator of cardiovascular health.
- Understanding exercise effects on different hamster models is crucial.
Purpose of the Study:
- To compare the effects of 4 and 16 weeks of exercise on cardiac function.
- To investigate exercise impacts on cardiomyopathic and normal hamsters.
- To assess changes in cardiac output, pressures, and heart calcium.
Main Methods:
- Exercise interventions of 4 and 16 weeks were applied.
- Cardiac output, stroke volume, heart rate, and pressures were measured.
- Left ventricular dP/dt and total heart calcium were analyzed.
Main Results:
- Exercise improved depressed cardiac function in cardiomyopathic hamsters.
- Exercise decreased elevated left ventricular diastolic pressure in cardiomyopathic hamsters.
- Exercise altered cardiac output, stroke volume, and pressures in normal hamsters, with longer duration yielding more changes.
Conclusions:
- Exercise training demonstrates beneficial effects on cardiac function in both healthy and diseased hamster models.
- Exercise duration influences the extent of cardiovascular adaptations.
- Exercise may modulate heart calcium levels, particularly with longer training periods.
Abstract:
1. Comparisons of the effects of 4 and 16 weeks of exercise were made on; cardiac output, stroke volume, heart rate, left intraventricular systolic and diastolic pressures, dP/dt, and heart calcium in the Bio 14.6 cardiomyopathic and F1 B hamsters. 2. In the cardiomyopathic hamster the cardiac output, stroke volume, left intraventricular systolic pressure and dP/dt, which were all depressed in the age related sedentary animals, were increased by both periods of exercise. The left intraventricular diastolic pressure which was elevated was likewise decreased by both exercise periods. Only the 16 week exercise period decreased the resting heart rate. 3. In the normal F1 B hamster, both periods of exercise increased the cardiac output and stroke volume while the left intraventricular systolic pressure was decreased. Only the 16 week exercise decreased the resting heart rate and left intraventricular diastolic pressure and increased the left ventricular dP/dt. 4. Both periods of exercise increased the total heart calcium in the Bio 14.6 hamster while the heart calcium in the F1 B was increased only by the 16 week exercise period.
