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Related Experiment Videos

Upper vs lower extremity arterial function after spinal cord injury.

Lee Stoner1, Manning Sabatier, Leslie VanhHiel

  • 1Department of Kinesiology, University of Georgia, Ramsey Center, Athens, GA 30602-6552, USA. Lee79@uga.edu

The Journal of Spinal Cord Medicine
|June 3, 2006
PubMed
Summary

Spinal cord injury (SCI) impairs arterial function, particularly in the legs, compared to arms. Cardiovascular health interventions for SCI patients should focus on leg artery assessments.

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Area of Science:

  • Cardiovascular Physiology
  • Neuroscience
  • Vascular Biology

Background:

  • Spinal cord injury (SCI) can significantly impact systemic cardiovascular health.
  • Arterial function, including flow-mediated dilatation (FMD) and arterial range, may be compromised following SCI.
  • Comparative analysis of arm and leg arterial function in SCI is crucial for understanding differential effects.

Purpose of the Study:

  • To investigate the effects of spinal cord injury (SCI) on arterial diameter, flow-mediated dilatation (FMD), and arterial range.
  • To compare arterial function between individuals with SCI and non-disabled subjects.
  • To determine if decrements in arterial function are more pronounced in the legs versus the arms of individuals with SCI.

Main Methods:

  • Ultrasound imaging was used to capture B-mode images of radial (arm) and posterior tibial (leg) arteries.

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  • Measurements included resting diameter, occluded diameter, and post-ischemic diameters to assess arterial function.
  • Hierarchical linear modeling was employed to analyze the data, accounting for the study's nested design.

    • Main Results:

    • Individuals with SCI exhibited significantly lower systemic FMD compared to non-disabled subjects (9.3% vs. 12.3%, P=0.035).
    • Reduced leg FMD was the primary driver of the systemic difference, with SCI legs showing impaired function (7.0% vs. 11.5% in SCI arms, P=0.010).
    • Arterial range was also lower in individuals with SCI (0.79 mm vs. 1.00 mm, P=0.043), predominantly due to diminished leg arterial range (0.56 mm vs. 0.81 mm in SCI arms, P=0.030).

    Conclusions:

    • Arterial function appears to deteriorate more significantly in the legs than in the arms of individuals with SCI.
    • These findings suggest that leg arteries are disproportionately affected by spinal cord injury.
    • Future cardiovascular health interventions for SCI populations should incorporate assessments of leg arterial function.