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Related Experiment Videos

Delayed sleep phase syndrome response to melatonin.

M Dahlitz1, B Alvarez, J Vignau

  • 1Department of Neurology, King's College School of Medicine and Dentistry, University of London, UK.

Lancet (London, England)
|May 11, 1991
PubMed
Summary
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Melatonin significantly advanced sleep and wake times in individuals with delayed sleep phase syndrome. This study suggests melatonin acts as a phase-setter for sleep-wake cycles.

Area of Science:

  • Chronobiology
  • Sleep Medicine

Background:

  • Delayed sleep phase syndrome (DSPS) is a circadian rhythm disorder characterized by a persistent difficulty in falling asleep and waking up at conventional times.
  • Melatonin, a hormone regulating the sleep-wake cycle, has been explored for its therapeutic potential in circadian rhythm disorders.

Purpose of the Study:

  • To investigate the effects of melatonin on the sleep-wake cycle in subjects diagnosed with delayed sleep phase syndrome.
  • To determine if melatonin administration can advance sleep onset and wake times in DSPS patients.

Main Methods:

  • A randomized, double-blind, placebo-controlled trial was conducted involving 8 subjects with DSPS.
  • Subjects received either melatonin (5 mg daily) or a placebo for 4 weeks, with a 1-week washout period.
  • Melatonin or placebo was administered at 2200 h, 5 hours before the subjects' habitual sleep onset time.

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Main Results:

  • Melatonin treatment resulted in a significant advancement of both sleep onset time (mean advance 82 minutes) and wake time (mean advance 117 minutes) compared to placebo (p < 0.01).
  • Mean total sleep time was slightly reduced during melatonin treatment (8 h 12 min) compared to placebo (8 h 46 min).
  • The alertness acrophase, an indicator of the timing of peak alertness, remained unchanged by melatonin treatment.

Conclusions:

  • Melatonin administration effectively advances sleep and wake times in individuals suffering from delayed sleep phase syndrome.
  • The findings support the role of melatonin as a phase-setting agent for the sleep-wake cycle in DSPS.
  • While melatonin advances sleep timing, its effect on total sleep duration and alertness timing warrants further investigation.