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Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube
Published on: April 28, 2020
Does instant coffee prevent acute liver injury induced by carbon tetrachloride (CCl(4))?
Ibrahim Hanifi Ozercan1, Adile Ferda Dagli, Bilal Ustundag
1Fırat University, Faculty of Medicine, Department of Pathology, 23119 Elazig, Turkey.
Objective:
To investigate the protective effect of instant coffee (IC) on acute liver injury induced by CCl(4).
Methods:
The study included 32 rats which were allocated to four groups: control (n: 8), CCl(4) (n: 8), CCl(4)+IC (n: 8) and IC (n: 8). Malondialdehyde, which is a lipid peroxidation product, and levels of antioxidant capacity were measured and histopathological data were compared.
Results:
It was seen in the study that lipid peroxidation products that increased in the plasma and liver tissue of the CCl(4) group decreased by IC administration. There was an increase in the measured antioxidant parameters, which were total antioxidant capacity (TAOC), sulphydryl (SH) and ceruloplasmin levels. Histopathologically, it was found that inflammation and necrosis which increased in the group administered CCl(4) decreased significantly with IC administration, but there steatosis did not change.
Conclusions:
It was seen that IC had a protective role in acute liver injury induced by CCl(4), but did not affect steatosis.
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