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Related Experiment Videos

Neurons in V1 patch columns project to V2 thin stripes.

Lawrence C Sincich1, Cristina M Jocson, Jonathan C Horton

  • 1Beckman Vision Center, University of California-San Francisco, San Francisco, CA 94143-0730, USA.

Cerebral Cortex (New York, N.Y. : 1991)
|June 3, 2006
PubMed
Summary

Connections between the primary visual cortex (V1) and second visual area (V2) in primates are detailed. While most V1 input to V2 thin stripes originates from layer 2/3 patches, other layers also contribute, with layer 5/6 input being non-specific.

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Area of Science:

  • Neuroscience
  • Visual System Research
  • Primate Brain Anatomy

Background:

  • Connections between primate visual areas V1 and V2 are organized by cytochrome oxidase (CO) activity.
  • V1 patches project to V2 thin stripes, and interpatches project to pale and thick stripes.
  • Previous studies suggested V1 layer 2/3 exclusively projects to V2 thin stripes.

Purpose of the Study:

  • To re-examine the laminar origin of V1 input to macaque V2 thin stripes.
  • To investigate the relationship between V1 projection patterns and CO activity in V2.

Main Methods:

  • Injections of cholera toxin-B (CTB-Au) retrograde tracer into macaque V2 thin stripes.
  • Analysis of the laminar location of retrogradely labeled cells in V1.
  • Correlation of labeled cell distribution with cytochrome oxidase (CO) patches in V1.

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Main Results:

  • The majority of V1 cells projecting to V2 thin stripes were found in layer 2/3.
  • Significant populations of projecting cells were also identified in V1 layers 4A, 4B, and 5/6.
  • Cells in layers 2/3, 4A, and 4B formed patch-like columns projecting to V2 thin stripes, while layer 5/6 cells were scattered.

Conclusions:

  • The primary V1 projection to V2 thin stripes originates mainly from layer 2/3 patches.
  • Multiple V1 layers contribute input to V2 thin stripes, challenging previous exclusivity claims.
  • V1 layer 5/6 projections to V2 thin stripes do not follow the patch/interpatch organization.