Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Community-based therapy for children with multidrug-resistant tuberculosis.

Peter C Drobac1, Joia S Mukherjee, J Keith Joseph

  • 1Social Medicine and Health Inequalities, Brigham and Women's Hospital, Boston, MA 02120, USA. pdrobac@partners.org

Pediatrics
|June 3, 2006
PubMed
Summary

Treatment for multidrug-resistant tuberculosis in children in Lima, Peru, was successful, with 95% cure rates. The therapy was well-tolerated, demonstrating that pediatric multidrug-resistant tuberculosis can be managed effectively even in resource-poor settings.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-release tuberculosis risk among formerly incarcerated populations in Lima Peru.

Nature communications·2026
Same author

Quantifying within-household tuberculosis transmission: a systematic review and prospective cohort study.

International journal of epidemiology·2026
Same author

Transmissibility and Disease Progression of Asymptomatic Mycobacterium tuberculosis Infection, Lima, Peru.

Emerging infectious diseases·2026
Same author

When are uncontrolled trials in TB scientifically and ethically justified: Borrowing wisdom from early AIDS clinical trials.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

MUTTON-HF: Rationale and Design of a Study of an Indigenous Food is Medicine Intervention.

Circulation. Heart failure·2026
Same author

Feasibility of an Indigenous Food Is Medicine Program for Patients With Heart Failure in Rural Navajo Nation: The MUTTON-HF Nonrandomized Clinical Trial.

JAMA network open·2026

Area of Science:

  • Pediatric infectious diseases
  • Global health epidemiology
  • Tuberculosis research

Background:

  • Multidrug-resistant tuberculosis (MDR-TB) poses a significant global health challenge, particularly in high-prevalence urban settings.
  • Children with MDR-TB often present with complex clinical conditions, including malnutrition and severe radiographic findings.
  • Effective management strategies for pediatric MDR-TB are crucial, especially in resource-limited environments.

Purpose of the Study:

  • To describe the management of multidrug-resistant tuberculosis (MDR-TB) in children.
  • To assess the tolerability of second-line antituberculosis agents in pediatric patients.
  • To report treatment outcomes for children with MDR-TB in Lima, Peru.

Main Methods:

  • Retrospective analysis of 38 children under 15 years old diagnosed with or suspected of having MDR-TB.

Related Experiment Videos

  • Individualized, supervised treatment regimens using at least five first- or second-line drugs for 18–24 months.
  • Data collected on clinical presentation, treatment, adverse events, and outcomes.

    • Main Results:

    • 45% of children had malnutrition or anemia; 29% had severe radiographic findings.
    • 42% of children experienced adverse events, but none required prolonged therapy suspension.
    • A high cure rate of 95% (36 of 38 children) was achieved, with low mortality (2.5%) and default rates (2.5%).

    Conclusions:

    • Multidrug-resistant tuberculosis in children can be successfully treated in resource-poor settings.
    • Second-line antituberculosis agents are generally well-tolerated in pediatric populations.
    • Effective MDR-TB management in children is feasible even in high-prevalence urban areas like Lima, Peru.