Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperthyroidism is associated with higher plasma endothelin-1 concentrations.

Chih-Hsun Chu1, Jenn-Kuen Lee, Hsiu-Man Keng

  • 1Division of Endocrinology and Metabolism, Kaohsiung Veterans General Hospital, Taiwan.

Experimental Biology and Medicine (Maywood, N.J.)
|June 3, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two Birds, One Stone: Simultaneous LAA Occlusion and Lateral Mitral PVL Closure.

JACC. Case reports·2026
Same author

Taiwanese consensus statement on the use of diabetes-specific formula: Scientific evidence.

Journal of diabetes investigation·2026
Same author

Effectiveness and safety of connected solutions among people with type 2 diabetes uncontrolled on oral anti-diabetic drugs: A randomized real-world study on Insultrate.

Primary care diabetes·2026
Same author

Novel EBU Catheter-Assisted Parallel Wire Technique for Difficult Aortic Valve Crossing (EUPASS).

JACC. Asia·2026
Same author

Cost-Effectiveness of Artificial Intelligence Assisted Screening for Diabetic Retinopathy: A Markov Model.

Diabetes/metabolism research and reviews·2026
Same author

Predictive value of residual vessel fractional flow reserve for optimizing coronary physiology postrevascularization.

Coronary artery disease·2025

Treating hyperthyroidism lowers plasma endothelin-1 (ET-1) and improves insulin resistance. This study found hyperthyroid patients have higher ET-1, which decreased after treatment, along with reduced insulin resistance index (HOMA-R).

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Cardiovascular Research

Background:

  • Hyperthyroidism is linked to altered metabolic and cardiovascular markers.
  • Endothelin-1 (ET-1) plays a role in vascular tone and may be implicated in thyroid dysfunction.
  • Insulin resistance is a growing concern in metabolic health.

Purpose of the Study:

  • To investigate the impact of hyperthyroidism treatment on plasma endothelin-1 (ET-1) concentrations.
  • To assess changes in the insulin resistance index following normalization of thyroid function.
  • To explore correlations between ET-1, thyroid hormones, and insulin resistance parameters.

Main Methods:

  • Studied 20 hyperthyroid patients and 31 controls.
  • Measured plasma ET-1, thyroid hormones (T3, FT4), glucose, and insulin.

Related Experiment Videos

  • Calculated insulin resistance using the Homeostasis Model Assessment (HOMA-R) before and after treatment.

    • Main Results:

    • Hyperthyroid patients exhibited significantly higher plasma ET-1 levels compared to controls.
    • Treatment of hyperthyroidism led to a significant decrease in plasma ET-1 concentrations.
    • Post-treatment, serum glucose, body weight-adjusted insulin, and HOMA-R index were significantly reduced.
    • Plasma ET-1 positively correlated with T3 and FT4; HOMA-R correlated with BMI, body fat, T3, and FT4.

    Conclusions:

    • Hyperthyroidism is associated with elevated plasma ET-1 levels.
    • Correction of hyperthyroidism effectively reduces plasma ET-1 and improves insulin resistance.
    • These findings highlight the interconnectedness of thyroid function, vascular peptides, and metabolic health.