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Updated: Aug 8, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Genetic risk for ischemic and hemorrhagic stroke
Yoshiji Yamada1, Norifumi Metoki, Hidemi Yoshida
1Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima-machiya, Tsu, Mie 514-8507, Japan. yamada@gene.mie-u.ac.jp
Arteriosclerosis, Thrombosis, and Vascular Biology
|June 3, 2006
Summary
Genetic variations in Interleukin-6 (IL-6) and other genes are linked to stroke risk. Specific IL-6 polymorphisms may predict atherothrombotic cerebral infarction and intracerebral hemorrhage, while UCP3, TNF, and PKD1-like gene variants are associated with subarachnoid hemorrhage risk.
Area of Science:
- Genetics
- Neurology
- Cardiovascular Science
Background:
- Stroke is a leading cause of death and disability worldwide.
- Identifying genetic risk factors is crucial for stroke prevention and personalized medicine.
Purpose of the Study:
- To identify gene polymorphisms associated with the genetic risk of ischemic or hemorrhagic stroke.
- To investigate the association between specific gene variants and different stroke subtypes in a Japanese population.
Main Methods:
- An association study was conducted on 3151 Japanese individuals (1141 stroke patients and 2010 controls).
- Genotyping for 202 polymorphisms across 152 genes was performed using suspension array technology.
- Multivariable logistic regression analysis adjusted for conventional risk factors was employed.
Main Results:
- The -572G-->C polymorphism in the interleukin-6 (IL-6) gene was significantly associated with atherothrombotic cerebral infarction (P<0.001) and intracerebral hemorrhage (P<0.001).
- The -55C-->T polymorphism in the uncoupling protein 3 (UCP3) gene, the -863C-->A polymorphism in the tumor necrosis factor (TNF) gene, and the G-->A (Gly243Asp) polymorphism in the polycystic kidney disease 1-like (PKD1-like) gene were significantly associated with subarachnoid hemorrhage.
Conclusions:
- IL-6 gene polymorphisms may be valuable for assessing genetic risk in atherothrombotic cerebral infarction and intracerebral hemorrhage.
- UCP3, TNF, and PKD1-like gene polymorphisms may aid in assessing the risk for subarachnoid hemorrhage.
- Further validation in independent cohorts is necessary to confirm these findings.
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