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Related Experiment Videos

Serotonin transporter polymorphisms and persistent, pervasive childhood aggression.

Joseph H Beitchman1, Lidia Baldassarra, Helene Mik

  • 1Division of Child and Adolescent Psychiatry, University of Toronto, and the Centre for Addiction and Mental Health, 250 College St., Toronto, Ont. Canada, M5T 1R8. Joe_Beitchman@camh.net

The American Journal of Psychiatry
|June 3, 2006
PubMed
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The serotonin transporter promoter polymorphism (5-HTTLPR) gene is linked to childhood aggression. Specifically, "low expressing" variants of this gene were significantly associated with aggressive behaviors in children.

Area of Science:

  • Genetics
  • Neuroscience
  • Developmental Psychology

Background:

  • Childhood aggression is a complex behavior with potential genetic underpinnings.
  • The serotonin transporter gene (5-HTT) plays a crucial role in serotonin signaling, influencing mood and behavior.
  • Genetic variations in the 5-HTT gene, such as the 5-HTT variable-number-tandem-repeat and the serotonin transporter promoter polymorphism (5-HTTLPR), are investigated for their role in behavioral outcomes.

Purpose of the Study:

  • To investigate the association between the serotonin transporter (5-HTT) gene, specifically the 5-HTT variable-number-tandem-repeat and the serotonin transporter promoter polymorphism (5-HTTLPR) including its Lg allelic variant, and childhood aggression.
  • To determine if specific genetic variants of 5-HTTLPR are more prevalent in children with extreme aggression.

Main Methods:

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  • Genotyping of 5-HTTLPR and 5-HTT variable-number-tandem-repeat was performed on clinically referred children with a history of extreme aggression (N=77 for 5-HTTLPR, N=78 for 5-HTT VNTR).
  • Genotype frequencies of aggressive children were compared with those of healthy control subjects.

Main Results:

  • A significant association was found between "low expressing" genotypic variants of the 5-HTTLPR polymorphism (S/S, Lg/S, Lg/Lg) and childhood aggression.
  • These findings suggest that specific genetic profiles related to serotonin transporter function are linked to aggressive behavior.

Conclusions:

  • This study provides the first evidence of a significant association between the 5-HTTLPR gene and childhood aggression.
  • The results highlight the potential role of serotonin transporter genetics in the development of severe aggressive behaviors in children.