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[Curable dementia and panarteritis nodosa].

J R Harlé1, P Disdier, A Ali Cherif

  • 1Service de Médecine Interne, Hôpital de la Timone, Marseille.

Revue Neurologique
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Cerebral polyarteritis nodosa recurrence caused lymphocytic meningitis and encephalitis. Effective treatment with methylprednisolone and cyclophosphamide led to neurological deficit regression.

Area of Science:

  • Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Polyarteritis nodosa (PAN) is a systemic vasculitis that can affect the central nervous system.
  • Cerebral involvement in PAN can manifest with diverse and severe neurological symptoms.

Observation:

  • A 64-year-old male presented with symptoms suggestive of cerebral recurrence of PAN.
  • The patient developed lymphocytic meningitis and encephalitis, leading to rapid cognitive decline and dementia.
  • Diagnostic procedures, including lumbar puncture and cerebral biopsy, confirmed lymphocytic meningitis and arteritis.

Findings:

  • The patient's neurological deficits showed significant regression after a six-month treatment course.
  • Treatment involved a combination of corticosteroids (methylprednisolone) and immunosuppressants (cyclophosphamide).

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Implications:

  • This case highlights the potential for severe neurological manifestations in recurrent PAN.
  • Prompt diagnosis and aggressive immunosuppressive therapy are crucial for managing CNS PAN.
  • Successful treatment outcomes underscore the efficacy of combined methylprednisolone and cyclophosphamide in this condition.