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Symptomatic C-cell hyperplasia associated with chronic lymphocytic thyroiditis.

P W Biddinger1, M F Brennan, P P Rosen

  • 1Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

The American Journal of Surgical Pathology
|June 1, 1991
PubMed
Summary
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This study reports the first case of symptomatic C-cell hyperplasia linked to chronic lymphocytic thyroiditis, resolving wheezing and flushing after treatment. The exact cause of these symptoms remains unidentified.

Area of Science:

  • Endocrinology
  • Oncology
  • Immunology

Background:

  • Chronic lymphocytic thyroiditis (CLT) is an autoimmune thyroid disease.
  • C-cell hyperplasia is a condition involving an overgrowth of C-cells in the thyroid.
  • CLT is rarely associated with C-cell hyperplasia.

Observation:

  • A 58-year-old man presented with episodic flushing and progressive wheezing.
  • He had a thyroid lesion and elevated calcitonin levels after pentagastrin stimulation.
  • Thyroidectomy revealed C-cell hyperplasia associated with CLT.

Findings:

  • C-cells stained positive for calcitonin and carcinoembryonic antigen (CEA).
  • Post-surgery, wheezing and flushing resolved, and calcitonin levels normalized.
  • Two of nine other CLT specimens showed minor C-cell hyperplasia without symptoms.

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Implications:

  • This is the first reported case of symptomatic C-cell hyperplasia associated with CLT.
  • The mechanism causing C-cell hyperplasia in CLT is unknown.
  • The specific substances causing the patient's symptoms were not identified.