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[Folate deficiency and neurologic disorders].

B Maufroy, J Zittoun, A Barois

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |January 20, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Serum folate deficiency is common in neurological disorders, particularly peripheral neuritis and cerebellar syndromes. Folic acid treatment showed potential benefits in some patients, suggesting a link between folate levels and neurological health.

    Area of Science:

    • Neurology
    • Biochemistry

    Context:

    • Neurological disorders encompass a wide range of conditions affecting the brain, spinal cord, and nerves.
    • Folate (vitamin B9) is essential for numerous bodily functions, including DNA synthesis and repair.

    Purpose:

    • To investigate the prevalence of serum folate deficiency in patients with neurological disorders.
    • To explore potential etiological factors and the therapeutic effect of folic acid supplementation.

    Summary:

    • Serum folate levels were assessed in 74 patients with diverse neurological conditions.
    • Low folate levels were observed in 63 patients, frequently associated with peripheral neuritis, cerebellar syndromes, and psychological disorders.
    • Identified contributing factors included alcoholism, malnutrition, diarrhea, and anti-epileptic drug use.

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    Impact:

    • Highlights a significant association between folate deficiency and various neurological conditions.
    • Suggests that folic acid supplementation may be a beneficial therapeutic strategy for certain neurological disorders.
    • Underscores the need for further research to establish definitive causal links and optimize treatment protocols.