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Updated: Aug 8, 2026
Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
Published on: August 19, 2012
Microwave assisted "click" chemistry for the synthesis of multiple labeled-carbohydrate oligonucleotides on solid
Camille Bouillon1, Albert Meyer, Sébastien Vidal
1Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5, France.
Abstract:
A versatile approach has been developed for the multiple labeling of oligonucleotides. First, three linkers as a H-phosphonate monoester derivative were condensed on a solid-supported T12 to introduce H-phosphonate diester linkages which were oxidized in the presence of propargylamine. Second, three galactosyl azide derivatives were conjugated to the solid-supported three-alkyne-modified T12 by a 1,3-cycloaddition so-called "click chemistry" in the presence of Cu(I) assisted by microwaves.
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