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Expression of the p73 protein in rectal cancers with or without preoperative radiotherapy
Daniella Pfeifer1, Jingfang Gao, Gunnar Adell
1Department of Oncology, Institute of Biomedicine and Surgery, Linköping University, Linköping, Sweden.
Purpose:
To investigate p73 expression in normal mucosa, primary tumor, and metastasis in relation to radiotherapy (RT) response and clinicopathologic/biologic variables in rectal cancers.
Methods And Materials:
p73 was immunohistochemically examined on biopsies (unirradiated, n=102), distant (from the large bowel, n=82), and adjacent (adjacent to primary tumor, n=89) normal mucosa samples, primary tumors (n=131), and lymph node metastasis (n=32) from rectal cancer patients participating in a clinical trial of preoperative RT. Seventy-four patients received surgery alone and 57 received additional RT.
Results:
Cytoplasmic p73 was increased in the primary tumor compared with the distant or adjacent mucosa (p
Conclusions:
Normal epithelial cells seem more sensitive to RT than tumor cells regarding p73 expression. Patients with p73-negative rectal tumors may have a lower risk of local recurrence after RT.
