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Applying the Growth Failure in CKD Consensus Conference: evaluation and treatment algorithm in children with chronic

John D Mahan1

  • 1Department of Pediatrics, Division of Pediatric Nephrology, The Ohio State University College of Medicine, Columbus, OH, USA. MahanJ@pediatrics.ohio-state.edu

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
|June 6, 2006
PubMed

Insights

Growth failure in children with chronic kidney disease (CKD) is common. New guidelines offer a framework for applying recombinant human growth hormone (rhGH) therapy to improve growth outcomes.

Area of Science:

  • Pediatric Nephrology
  • Endocrinology
  • Growth Disorders

Background:

  • Growth failure is a significant clinical issue in children with chronic kidney disease (CKD), impacting their overall health and increasing mortality.
  • Children with chronic renal insufficiency (CRI), defined by a glomerular filtration rate (GFR) <75 mL/min/1.73 m2, often experience growth impairment due to multifactorial causes.

Observation:

  • Abnormalities in the growth hormone (GH)-insulin-like growth factor (IGF)-I axis, alongside nutritional and metabolic challenges, contribute to growth failure in pediatric CKD.
  • Despite established safety and efficacy, the utilization of recombinant human growth hormone (rhGH) therapy for growth failure in children with CKD remains suboptimal.

Findings:

  • Recent guidelines from the Consensus Conference for Evaluation and Treatment of Growth Failure in Children with CKD provide a structured approach.
  • This paper emphasizes the practical application of these newly developed guidelines for managing growth failure in pediatric CKD patients.

Implications:

  • Implementing these guidelines can lead to improved growth outcomes for children suffering from CKD-related growth failure.
  • Wider adoption of rhGH therapy, guided by these recommendations, may address the current underutilization and enhance patient well-being.

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