Related Experiment Video
Updated: Aug 8, 2026
Murine Bilateral Renal Lymphadenectomy
Published on: December 30, 2025
Long-term survival after combination chemotherapy for bilateral renal malignant lymphoma in a dog
D J Batchelor1, S R Bright, P Ibarrola
1Small Animal Hospital, Department of Clinical Veterinary Science, University of Liverpool, Crown St, Liverpool, L7 7EX, United Kingdom. danb@liv.ac.uk
Case History:
A 6-year-old, entire male Flat-coated Retriever was presented with a history of lethargy, polydipsia and seizures. Clinical chemistry had shown marked azotaemia.
Clinical Findings And Diagnosis:
Radiography and ultrasonography revealed bilateral renomegaly, and cytology of fine needle aspirates from the kidneys was diagnostic of malignant lymphoma. The dog was treated with a modified high-dose cyclophosphamide-, vincristine-, and prednisolone-based chemotherapy protocol, achieved remission, and returned to normal quality of life. Survival time was 346 days from the time of diagnosis.
Clinical Relevance:
Malignant lymphoma in the kidneys of dogs has been considered to carry a uniformly poor prognosis. Long-term remission after medical treatment has not previously been reported. The favourable outcome in this case illustrates the limitations of clinical staging in determining the outcome for individual patients.