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Updated: Aug 8, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
BRAF mutation and AKAP9 expression in sporadic papillary thyroid carcinomas
Ju-Han Lee1, Eung Seok Lee, Young-Sik Kim
1Department of Pathology, College of Medicine, Korea University, Seoul, Korea.
Pathology
|June 7, 2006
Summary
The BRAF mutation is common in papillary thyroid cancer (PTC) and may aid in diagnosis and treatment. AKAP9-BRAF fusion is rare in sporadic PTC.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer.
- Identifying specific genetic mutations and protein expressions can improve diagnosis and treatment strategies for PTC.
Purpose of the Study:
- To investigate the prevalence of BRAF mutations in sporadic PTC.
- To examine the expression of AKAP9 protein in PTC.
- To determine the occurrence of AKAP9-BRAF fusion in sporadic PTC.
Main Methods:
- Analysis of 100 sporadic PTC specimens.
- Detection of BRAF mutations using molecular techniques.
- Evaluation of AKAP9 protein expression via immunohistochemistry.
Main Results:
- BRAF mutation was detected in 58% of sporadic PTC specimens, with specific frequencies across different PTC subtypes.
- All identified BRAF mutations involved a T-->A transversion at nucleotide 1796.
- BRAF mutation was significantly associated with extrathyroidal extension.
- AKAP9 protein was consistently observed as a perinuclear dot in all PTCs.
- No AKAP9-BRAF fusion was detected in the studied sporadic PTC cases.
Conclusions:
- BRAF mutation serves as a potential diagnostic and prognostic marker for PTC.
- BRAF mutation represents a potential therapeutic target for novel cancer treatments.
- AKAP9-BRAF fusion appears to be an infrequent event in sporadic PTC.
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