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Published on: March 17, 2020

Unusual extramedullary recurrences and breast relapse despite hepatic GVHD after allografting in Ph+-ALL

Ebru Koca1, Hakan Goker, Gulay S Guven

  • 1Hacettepe University, Division of Hematology, Department of Internal Medicine, Ankara, Turkey. ekoca@hacettepe.edu.tr

Hematology (Amsterdam, Netherlands)
|June 7, 2006
PubMed

Extramedullary recurrences with or without bone marrow involvement are reported in up to a half of leukemic relapses after BMT. Our report describes a case of an extramedullary recurrence and breast relapse after second-allografting in a female patient with Ph+-acute lymphoblastic leukemia (ALL), occurring when there was active hepatic GHVD. This case illustrates the complex relationship between graft-versus-host disease (GVHD) and graft-versus-leukemia since she had no evidence of leukemia in her marrow demonstrating 100% full-donor chimerism while she had ALL relapse in her breast.

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