Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Severe head injury: effect upon cellular immune function.

K B Quattrocchi1, E H Frank, C H Miller

  • 1Department of Neurosurgery, UC Davis Medical Center, Sacramento 95816.

Neurological Research
|March 11, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BMI is independently associated with ARDS, sepsis and multiorgan failure after major trauma-results of a high-volume retrospective observational cohort study.

Scandinavian journal of trauma, resuscitation and emergency medicine·2026
Same author

Biological sex, but not obesity, independently predicts anatomical injury patterns in trauma bay patients: a multivariate retrospective analysis of 2,128 patients.

Biology of sex differences·2026
Same author

Obesity significantly elevates thromboembolism risk in severe trauma, yet essential resuscitation with TXA and erythrocytes remains safe.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same author

Impact of trauma centre capacity and volume on the mortality risk of incoming new admissions.

BMJ military health·2020
Same author

Mathematical model of thrombin generation and bleeding phenotype in Amish carriers of Factor IX:C deficiency vs. controls.

Thrombosis research·2019
Same author

Physical inactivity and knee osteoarthritis in guinea pigs.

Osteoarthritis and cartilage·2019
Same journal

Does early gastrostomy tube placement after stroke improve functional recovery and quality of life? A literature-informed pathway-decomposition analysis.

Neurological research·2026
Same journal

Predictive ability of cardiac biomarkers for early risk stratification and 3-month functional outcomes after reperfusion therapy in acute ischemic stroke.

Neurological research·2026
Same journal

Luteolin reduces sciatic nerve damage and modulates TRPV1 and TRPM2 expression in diabetic rats.

Neurological research·2026
Same journal

Cholinergic regulation of memory retrieval: scopolamine reduces hippocampal neurotrophic and metabolic support.

Neurological research·2026
Same journal

Effect of intravenous thrombolysis on arterial and venous profiles in large-vessel occlusion stroke: a retrospective propensity score-matched study.

Neurological research·2026
Same journal

Association between post-treatment neuroimaging markers of cerebral small vessel disease and short-term efficacy of recombinant tissue plasminogen activator in acute stroke patients.

Neurological research·2026
See all related articles

Severe head injury significantly impairs cellular immunity, leading to a high infection rate. This study found reduced T-cell function and increased monocyte activity post-injury.

Area of Science:

  • Neuroimmunology
  • Trauma Immunology

Background:

  • Infection is a common complication after severe head injury.
  • The impact of severe head injury on immune function is not well understood.
  • Central nervous system modulation of immunity is known but poorly documented in head trauma.

Purpose of the Study:

  • To prospectively investigate cellular immune function in patients with severe head injury.
  • To determine the effects of head injury on immune cell activity and skin test responses.
  • To correlate immune changes with infection rates following injury.

Main Methods:

  • Delayed-type hypersensitivity (DTH) skin tests were used for in vivo immune assessment.
  • In vitro studies analyzed peripheral blood lymphocyte (PBL) phenotype and blastogenesis using phytohaemagglutinin (PHA).

Related Experiment Videos

  • Cellular immune parameters were measured in 20 patients with isolated severe head injury.

    • Main Results:

    • DTH skin tests showed anergy to antigens in the first two weeks post-injury.
    • PHA-stimulated PBL blastogenesis and T-cell markers (including helper T-cells and IL-2 receptors) significantly decreased.
    • A significant increase in monocyte percentage was observed, while B-cells and NK cells remained unchanged.

    Conclusions:

    • Severe head injury induces a state of cellular immune suppression.
    • Decreased helper T-cell activation may contribute to the high incidence of infection.
    • Further research is needed to understand the role of increased monocytes in head injury outcomes.