Related Experiment Video
Updated: Aug 8, 2026

Asthma Detection Research Based on Voice Signal Processing and Machine Learning
Published on: July 22, 2025
Role of vocal cord function and dysfunction in patients presenting with symptoms of acute asthma exacerbation
Subin Jain1, Venkata Bandi, Todd Officer
1Pulmonary Critical Care & Sleep Medicine, University of Louisville Health Sciences Center, Kentucky, USA. subin.jain@gmail.com
Abstract:
A total of 48 patients presenting to the emergency department as acute asthma exacerbation were prospectively studied. Rhinolaryngoscopy was conducted with simultaneous flow measurements and spirometry performed before and after the procedure. Measurements of the vocal cord opening during various phases of respiration were analyzed. Only 4 of 48 patients had anterior two-thirds closure of the vocal cords with a diamond-shaped opening posteriorly during expiration. One additional patient had inspiratory and expiratory closure of the vocal cords. The previously unreported high incidence of anterior two-thirds closure (10.4%) of the vocal cords suggests that the upper airway has a role to play in a significant number of patients presenting with symptoms of asthma exacerbation.
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