Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Unilateral multicystic dysplastic kidney: long term outcomes.

M Aslam1, A R Watson,

  • 1Children & Young People's Kidney Unit, Nottingham University Hospitals, Nottingham, UK.

Archives of Disease in Childhood
|June 7, 2006
PubMed
Summary

Most unilateral multicystic dysplastic kidneys (MCDK) involute over time, with 59% gone by age 10. Long-term follow-up is recommended for remaining renal tissue and impaired function, with conservative management generally justified.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Halide Double Perovskites: Insights into Structure, Defects, and Luminescence.

ACS applied materials & interfaces·2026
Same author

Cure or Truce? Rethinking Cancer Dormancy in Modern Oncology.

Clinical oncology (Royal College of Radiologists (Great Britain))·2025
Same author

An innovative electrochemical approach for selective and sensitive urea sensing using NiNPs modified GCE.

Scientific reports·2025
Same author

A Comparative Study of Endoscopic Dacryocystorhinostomy With and Without Stent Versus External DCR.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2024
Same author

Chemical Aspects of Halide Perovskite Nanocrystals.

Topics in current chemistry (Cham)·2024
Same author

Real world data on outcomes of anti-CD38 antibody treated, including triple class refractory, patients with multiple myeloma: a multi-institutional report from the Canadian Myeloma Research Group (CMRG) Database.

Blood cancer journal·2023

Area of Science:

  • Pediatric Nephrology
  • Urology
  • Medical Imaging

Background:

  • Antenatally detected unilateral multicystic dysplastic kidney (MCDK) is a common congenital anomaly.
  • Long-term outcomes and involution patterns of MCDK require further elucidation.

Purpose of the Study:

  • To assess the long-term follow-up of children diagnosed with unilateral MCDK before birth.
  • To document complications, the rate of involution over time, and renal function at 10 years of age.

Main Methods:

  • Prospective data from a regional registry of MCDK patients (1985-2004) were analyzed.
  • Children underwent serial ultrasound scans (USS) at 2, 5, and 10 years.

Main Results:

  • Complete involution of MCDK kidneys was observed in 33% by 2 years, 47% by 5 years, and 59% by 10 years.

Related Experiment Videos

  • No significant complications like hypertension, proteinuria, or malignancy were noted. Two patients developed obstruction in the contralateral kidney.
  • 19% of children had vesicoureteric reflux (VUR) into the contralateral kidney, without increased risk of UTIs or renal scarring. Mean GFR at 10 years was 86.4 ml/min/1.73 m2.

    • Conclusions:

    • Conservative management with clinical review and infrequent USS is appropriate for unilateral MCDK.
    • Continued follow-up is necessary for the 41% with persistent renal remnants and those with impaired GFR.
    • Micturating cystography can be deferred unless ultrasound reveals abnormalities in the contralateral kidney or ureter.