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Drug therapy during labor and delivery, part 2
Gerald G Briggs1, Stephanie R Wan
1Women's Pavilion, Miller Children's Hospital, Long Beach Memorial Medical Center, Long Beach, CA 90806, USA. jbriggs@memorialcare.org
Summary
This review examines drug therapy during labor and delivery, including medications for induction, pain management, and complications. Fetal and neonatal effects are generally benign, but risks exist for mother and infant.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Neonatal Medicine
Background:
- Labor and delivery involve various conditions requiring pharmacologic interventions.
- Maternal drug therapy during childbirth can impact fetal and neonatal outcomes.
- Many medications lack FDA-approved labeling for use during labor and delivery.
Purpose of the Study:
- To examine drug therapy for common conditions and complications during labor and delivery.
- To assess the fetal and neonatal effects of these drug therapies.
- To inform hospital pharmacists about critical medications for labor and delivery units.
Main Methods:
- Review of pharmacologic agents used in labor and delivery.
- Analysis of indications for drug use, including induction, pain, and complications.
- Evaluation of fetal and neonatal effects of maternal drug administration.
Main Results:
- Common therapies include oxytocin, prostaglandins, and analgesics.
- Other treatments address infections, HIV transmission, fetal lung maturity, preeclampsia, eclampsia, and preterm labor.
- While generally benign, fetal and neonatal effects carry risks.
Conclusions:
- Pharmacologic management is crucial for labor, delivery, and postpartum complications.
- Understanding medication benefits and limitations is vital for pharmacists.
- Ensuring rapid access to critical medications improves patient care during childbirth.
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