Related Experiment Video
Updated: Aug 8, 2026
07:45
Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
Published on: January 26, 2024
Viral lymphomagenesis
1Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, Texas 77030, USA.
Current Opinion in Hematology
|June 7, 2006
Summary
Viruses like Epstein-Barr virus are linked to lymphoma development. Targeting viral proteins offers new therapeutic strategies for these cancers, especially in immunosuppressed individuals.
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Several viruses, including Epstein-Barr virus (EBV), Human T-cell leukemia virus 1 (HTLV-1), Human herpes virus 8 (HHV-8), and Hepatitis C virus (HCV), are associated with lymphomagenesis.
- The presence of viral genomes within tumor cells presents opportunities for targeted therapeutic interventions.
Purpose of the Study:
- To review the association of various viruses with different types of lymphomas.
- To explore the therapeutic potential of targeting virus-encoded proteins and virus-modulated pathways in lymphoma treatment.
Main Methods:
- Review of existing literature on viral associations with lymphoma.
- Analysis of current and preclinical therapeutic strategies targeting viral components in lymphoma.
Main Results:
- Epstein-Barr virus (EBV) is implicated in B-cell lymphomas in immunosuppressed patients, Burkitt's lymphoma, T/NK lymphomas, and Hodgkin's disease.
- Antigen-specific T-cell immunotherapy shows efficacy in EBV-associated posttransplant lymphoma and EBV-positive Hodgkin's disease.
- Responses observed in Hepatitis C virus (HCV)-positive lymphomas with immune modulation, and preclinical studies focus on blocking EBV proteins.
Conclusions:
- The role of EBV and other viruses in lymphomagenesis is well-established in immunosuppressed patients but less clear in immunocompetent individuals.
- Viral genomes in lymphomas provide targets for novel therapies, including adoptive immunotherapy, interferon, and small molecules.
- Further research into virus-modulated cellular pathways can reveal additional therapeutic targets for lymphoma.
Related Concept Videos
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:51Mechanisms of Retrovirus-induced Cancers
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...