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Related Experiment Videos

Selenium long-term administration and its effect on mercury toxicity.

Ana I Cabañero1, Yolanda Madrid, Carmen Cámara

  • 1Departamento de Química Analítica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.

Journal of Agricultural and Food Chemistry
|June 8, 2006
PubMed
Summary

Chickens accumulate selenomethionine (SeMet) from their diet, making them a dietary source of this essential nutrient. Selenium (Se) can mitigate mercury (Hg) toxicity by promoting its demethylation.

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Area of Science:

  • Environmental Toxicology
  • Nutritional Biochemistry
  • Food Chain Bioaccumulation

Background:

  • Selenium (Se) and mercury (Hg) interactions are crucial in food chains.
  • Understanding Se bioaccumulation and its impact on Hg toxicity is vital for human health.
  • Chickens play a role in the plant-animal food chain, influencing nutrient transfer.

Purpose of the Study:

  • To investigate selenium bioaccumulation and bioaccessibility in chickens.
  • To assess the impact of dietary selenium on mercury toxicity.
  • To identify the forms of selenium and their distribution in chicken tissues.

Main Methods:

  • An in vivo experiment with 72 chickens under controlled dietary conditions.
  • Diets supplemented with mercury (Hg(II), MeHg) and selenium (Se(IV)).

Related Experiment Videos

  • Enzymatic and simulated human digestion of feed and chicken tissues (muscle, liver, kidney) to identify selenomethionine (SeMet).

    • Main Results:

    • Selenomethionine (SeMet) was identified in all analyzed chicken tissues and feed.
    • Kidneys were the primary target organs for total Se and SeMet, while muscle held the largest body store.
    • Mercury administration did not significantly alter SeMet distribution, suggesting an antagonistic effect.

    Conclusions:

    • Chickens are a significant source of dietary selenomethionine (SeMet) due to their diet and food chain transfer.
    • Selenium (Se) may counteract mercury (Hg) toxicity by facilitating methylmercury (MeHg) demethylation.
    • Further research is needed to fully elucidate the Se-Hg antagonism in vivo.