Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asparagine synthetase chemotherapy.

Nigel G J Richards1, Michael S Kilberg

  • 1Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA. richards@qtp.ufl.edu

Annual Review of Biochemistry
|June 8, 2006
PubMed
Summary

New research explores asparagine synthetase (ASNS) inhibitors for treating drug-resistant childhood acute lymphoblastic leukemia (ALL). These potent inhibitors offer a potential new avenue for patients who do not respond to current therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chemo-enzymatic one-pot depolymerization of β-chitin.

Chemical science·2026
Same author

A Foundational Shift in Models for Enzyme Function.

Journal of the American Chemical Society·2025
Same author

Assessing cancer therapeutic efficacy in vivo using [<sup>2</sup>H<sub>7</sub>]glucose deuterium metabolic imaging.

Science advances·2025
Same author

3D variability analysis reveals a hidden conformational change controlling ammonia transport in human asparagine synthetase.

Nature communications·2024
Same author

Arginine Kinase Activates Arginine for Phosphorylation by Pyramidalization and Polarization.

ACS catalysis·2024
Same author

A method for measurement of human asparagine synthetase (ASNS) activity and application to ASNS protein variants associated with ASNS deficiency.

Biology methods & protocols·2023

Area of Science:

  • Biochemistry
  • Pharmacology
  • Pediatric Oncology

Background:

  • Current childhood acute lymphoblastic leukemia (ALL) treatments use asparagine depletion, which can cause side effects.
  • Drug-resistant ALL may develop due to increased levels of the enzyme asparagine synthetase (ASNS).

Purpose of the Study:

  • To review recent advancements in understanding ASNS structure, function, and its role in drug-resistant ALL.
  • To discuss the development of novel ASNS inhibitors for therapeutic applications.

Main Methods:

  • Review of current literature on ASNS.
  • Analysis of ASNS structure and catalytic mechanisms.
  • Discussion of newly developed ASNS inhibitors.

Main Results:

  • ASNS up-regulation is linked to asparaginase resistance in ALL.
  • First mechanism-based nanomolar ASNS inhibitors have been successfully prepared and characterized.

Conclusions:

  • Targeting ASNS with potent inhibitors shows promise for treating drug-resistant childhood ALL.
  • Further development of ASNS inhibitors could lead to more effective therapies for ALL patients.

Related Experiment Videos