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E-selectin S128R polymorphism and severe coronary artery disease in Arabs

Khaled K Abu-Amero1, Olayan M Al-Boudari, Gamal H Mohamed

  • 1Genetics Department, King Faisal Specialist Hospital and Research Centre (MBC-03), P, O, Box 3354, Riyadh 11211, Saudi Arabia. kamero@kfshrc.edu.sa

BMC Medical Genetics
|June 8, 2006
PubMed

Insights

The E-selectin S128R polymorphism is linked to coronary artery disease (CAD) in Saudi Arabs. While univariate analysis showed an association, it was not significant in multivariate analysis for CAD risk factors.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • The E-selectin p. S128R (g. A561C) polymorphism has been linked to coronary artery disease (CAD) in various populations.
  • Limited data exists on the association between this E-selectin polymorphism and CAD in Arab populations.

Purpose of the Study:

  • To investigate the relevance of the E-selectin S128R polymorphism in severe CAD among Saudi Arabs.
  • To examine the association between this polymorphism and CAD risk factors in the Saudi population.

Main Methods:

  • Genotyping of Saudi Arabs for the E-selectin S128R polymorphism using PCR and restriction enzyme digestion.
  • Analysis of 556 patients with severe CAD and 237 angiographically confirmed control subjects.

Main Results:

  • The frequency of the mutant 128R allele was significantly higher in CAD patients (11%) compared to controls (6%) (OR=1.76, p=0.007).
  • Univariate analysis indicated a significant association between the 128R allele and CAD.
  • Multivariate analysis, including CAD risk factors, did not show a significant association for the 128R allele.

Conclusions:

  • The E-selectin p. S128R (g. A561C) polymorphism was associated with angiographic CAD in Saudi Arabs via univariate analysis.
  • This association was not maintained in multivariate analysis when considering CAD risk factors.
Abstract

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