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Updated: Aug 8, 2026

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
Published on: April 21, 2015
[Regulation of cytokine production in inflammatory bowel disease]
Laura Ferrero-Miliani1, Jakob Benecidt Seidelin, Ole Haagen Nielsen
1Amtssygehuset i Herlev, Medicinsk Gastroenterologisk Afdeling C. laufer01@herlevhosp.kbhamt.dk
Abstract:
Interleukin-1beta (IL-1beta) is a pivotal mediator in the inflammatory immune response that is characteristic of a number of chronic disorders. The etiology and pathophysiology of inflammatory bowel disease (IBD) have for many years been an enigma. The recent identification of the inflammasome, a multiprotein complex responsible for interleukin-1beta converting enzyme (ICE, caspase-1) activation, has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets.
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