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Acetaminophen induced pancreatitis

H C Mofenson1, T R Caraccio, H Nawaz

  • 1Long Island Regional Poison Control Center, Nassau County Medical Center, East Meadow, New York.

Journal of Toxicology. Clinical Toxicology
|January 1, 1991
PubMed

Insights

Acetaminophen overdose can cause acute pancreatitis, even with small ingestions. This case highlights a patient

Area of Science:

  • Toxicology
  • Gastroenterology
  • Pharmacology

Background:

  • Acetaminophen (APAP) overdose is a common cause of acute liver failure.
  • Acute pancreatitis is a rare but serious complication of APAP toxicity.

Observation:

  • A patient presented with acute pancreatitis after ingesting 9.75-13 g of acetaminophen.
  • This represents the smallest reported dose associated with APAP-induced pancreatitis.
  • The patient exhibited liver and renal impairment, ileus, and ascites.

Findings:

  • Despite late treatment initiation and poor prognostic indicators, the patient achieved full recovery.
  • This case underscores the potential for severe gastrointestinal and systemic complications from APAP overdose.
  • Complete recovery is possible even in critical cases with timely supportive care.

Implications:

  • Clinicians should consider acute pancreatitis in patients with acetaminophen overdose, regardless of the ingested amount.
  • Early recognition and management of APAP toxicity are crucial for preventing severe outcomes.
  • Further research is needed to elucidate the mechanisms of APAP-induced pancreatitis and optimize treatment strategies.

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