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Ras superfamily and interacting proteins database.

Andre Bernards1

  • 1Massachusetts General Hospital, Center for Cancer Research, Charlestown, Massachusetts, USA.

Methods in Enzymology
|June 8, 2006
PubMed
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Less than 2% of human and Drosophila genes encode Ras superfamily proteins or their regulators. A new database provides access to this information and related effector proteins for GTPase research.

Area of Science:

  • Genetics
  • Molecular Biology
  • Biochemistry

Background:

  • Understanding protein families with similar functions is crucial for geneticists and researchers.
  • The Ras superfamily plays significant roles in cellular signaling pathways.

Purpose of the Study:

  • To determine the proportion of human and Drosophila genes encoding Ras superfamily members and their regulators.
  • To create a database for accessing information on Ras superfamily proteins and effectors.

Main Methods:

  • Genome-wide survey of human and Drosophila genes.
  • Identification of Ras superfamily members and their regulators.
  • Compilation of a specialized database.

Main Results:

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  • Fewer than 2% of genes in both human and Drosophila genomes encode Ras superfamily members or their regulators.
  • A database was created containing information on these proteins.
  • The database includes approximately 360 putative Ras superfamily effector proteins.

    • Conclusions:

    • Ras superfamily proteins and their regulators represent a small fraction of genes in these genomes.
    • The compiled database serves as a valuable resource for researchers studying GTPase biology.