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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}

Mark P Rubinstein1, Marek Kovar, Jared F Purton

  • 1Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Proceedings of the National Academy of Sciences of the United States of America
|June 8, 2006
PubMed
Summary

Soluble Interleukin-15 (IL-15) activity is enhanced by binding to Interleukin-15 Receptor alpha (IL-15Ralpha). This complex selectively expands memory CD8+ T cells and natural killer cells, unlike Interleukin-2 (IL-2).

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