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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Olfactory neuroblastoma in a horse
Jyoji Yamate1, Takeshi Izawa, Keiko Ogata
1Department of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University, Osaka, Japan.
The Journal of Veterinary Medical Science
|June 8, 2006
Summary
A rare olfactory neuroblastoma, a type of nasal cavity tumor, was diagnosed in an 11-year-old thoroughbred gelding. This equine tumor exhibited varied histological features and neurogenic markers.
Area of Science:
- Veterinary Pathology
- Equine Oncology
- Neuro-oncology
Background:
- Olfactory neuroblastoma is a rare tumor arising from the olfactory epithelium.
- Equine nasal tumors are uncommon, with limited documented cases of this specific neoplasm.
Observation:
- An 11-year-old thoroughbred gelding presented with a right nasal cavity tumor.
- Histopathological examination revealed round to oval cells with scant cytoplasm and hyperchromatic nuclei.
- Features such as Homer-Wright rosettes, pseudorosettes, and microcysts were observed.
Findings:
- Immunohistochemical analysis showed neoplastic cell reactivity to vimentin, S-100 protein, neuron-specific enolase, glial fibrillary acidic protein, and microtube-associated protein.
- These immunoreactivity patterns indicated a neurogenic origin.
- The tumor was diagnosed as an olfactory neuroblastoma based on combined histological and immunohistochemical findings.
Implications:
- This case highlights the histological variability of olfactory neuroblastoma, even in non-human species.
- Understanding the neurogenic nature and diverse presentation of this tumor is crucial for accurate diagnosis in veterinary oncology.
- Further research into equine nasal tumors can improve diagnostic and potentially therapeutic strategies.
